The JASCO HT-SFC system achieves high-throughput chromatographic analysis employing the AS-2059-SF Autosampler and automated column selection switching valve. It allows faster method development of multiple samples compared with normal HPLC or SFC. By using the CD-2095 Circular Dichroism detector and a chiral separation column, chiral compounds can be analyzed in a short period of time. Supercritical mobile phase offers a low pressure drop across the column so that a high flow rate can be applied, enabling shorter analysis time without sacrificing resolution.

Schematic FLow Diagram of the System

1. Liquid carbon dioxide cylinder
2. Modifier
3. PU-2080-CO2 CO2 delivery pump
4. PU-2080 delivery pump for modifier
5. Solvent selector valve
6. Stop valve
7. Safty valve
8. Mixer
9. Accumulator
10. AS-2059-SF autosampler
11. HV-2080-03 column selector valve
12. Chiral column
13. CO-2060 column oven
14. MD-2015 diode array detector with high pressure flow cell
15. CD-2095 circular dichroism detector with high pressure flow cell
16. BP-2080 automatic back pressure regulator