The figure above is an example of a DSC measurement result comparing a non-pulverized (original) and a pulverized (mill) pharmaceutical sample. In the DSC measurement result of the original or non-pulverized material, an endothermic peak due to melting and an exothermic peak due to re-crystallization continuously occurred at 160℃, and then an endothermic peak due to melting is seen at 180℃. On the contrary, the endothermic as well as the exothermic reaction at 160℃found in the non-pulverized (original) are not observed in the mechanically-pulverized (mill) sample and only the endothermic peak due to melting at 180℃ is found. Both measurement results also show differences in endothermic peak caused by dehydration near room temperature. The external application of mechanical energy on the sample gives rise to physical changes (mechanochemical effect) which may cause differences in measurement results.