Kính hiển vi lực nguyên tử NanoWizard V Khoa học Sinh học
Automated quantitative nano-mechanical imaging
Liên hệ
NanoWizard® V BioScience
The JPK NanoWizard® V combines high spatio-temporal resolution with a large scan area, flexible experiment design, and out-standing integration with advanced optical microscope systems. The automated setup, alignment, and re-adjustment of system parameters opens new possibilities for long-term, self-regulating experiment series.
Discover the 5th Generation BioAFM
NanoWizard V is expected to significantly advance our understanding of dynamic cellular processes and molecular mechanisms. Its PeakForce-QI mode enables fast and flexible quantitative nanomechanical measurements—significantly extending the capabilities of AFM—while its automated, remote-control, and fast-scanning capabilities provide high-throughput, high-performance imaging of even complex experiments.
NanoWizard V features novel scanner and sensor technologies and state-of-the-art control software that encompasses an intuitive, workflow-based graphical user interface (GUI) to ensure true, easy-to-use AFM operation.
- Unmatched ease of use
- Speed for dynamics and improved throughput
- Automated, high pixel density mapping and imaging
NanoWizard V BioScience setup on Zeiss Axio Observer with tablet control.
- From the pioneers of BioAFM with over 25 years of experience in developing BioAFMs
- Recognized by an install base of over 1000 JPK/Bruker BioAFMs across the globe
- Proven by 8500+ publications with biological significance
- Supported by dedicated cantilever development for high-resolution imaging and customized applications
- Paving the way for new scientific discoveries with:
· PeakForce-QI, PeakForce Tapping®, PeakForce QNM®, QI
· Single Molecule Force Spectroscopy (SMFS)
· Single Cell Force Spectroscopy (SCFS)
· DirectOverlay 2 for AFM in conjunction with advanced optical microscopy
· New software environment V8
· Features the latest ExperimentPlanner and ExperimentControl
· Accessories for high NA optics and AFM, environment control, and more
Latest Technology for Maximum Efficiency
Highest performance BioAFM
Featuring an enhanced, workflow-based design with intuitive user guidance in the new SPM V8 software, the NanoWizard V empowers beginners and experts alike to acquire highest quality, reproducible data. The system’s high degree of automa-tion improves productivity and maximizes throughput. State-of-the-art analysis and batch processing routines ensure scientific accuracy and statistical data reliability.
- Adaptive intelligent scanning routines enable faster scanning rates of up to 400 lines/sec
- Lowest noise scanner and detection system ensure high-resolution data and unrivalled performance on inverted optical microscopes
- PeakForce-QI, the symbiosis of PeakForce Tapping and QI modes, delivers the fastest, most advanced force control for highly delicate samples
Fastest automated BioAFM for corrugated samples on an inverted microscope
- Visualize dynamics with Bruker’s Nested Scanner and latest feedback technologies
- Bruker’s proven DirectDrive increases cantilever excitation stability
- Active balancing provides faster scanning over large scan ranges
- Improved productivity and maximized throughput enables better statistics
- Intelligent optimization routines deliver quantitative nanomechanics
Most intuitive BioAFM operations
- Fundamental ease-of-use features
- User management, ideal for multi-user facilities
- Automated setup and workflow
- Single-click cantilever calibration
- Single-click optical image calibration
- Extended optical viewing field for AFM with stitching feature
- Long-term, unattended experimental procedures
- Remote operation capabilities
- Optimized storage of parameters and favorites
- Intuitive integration of data processing routines
Tapping mode topography image of Annexin 5 protein on lipid membrane in buffer acquired at 40 Hz line rate showing the occupation density of centric trimers in 2D honeycomb structure. Scan size 1.3 µm x 1.3 µm, height range 8.0 nm.
Fast tapping mode topography image acquired at 170 Hz line rate of Annexin 5 protein on lipid membrane in buffer. The arrows depict the occupation of a centric trimer from solution in the 2D crystal structure 12 seconds (8 frames) later. Scan size 96 nm x 96 nm, height range 1.0 nm.
Left: Topography image of atomic lattice of mica in liquid. Image taken in closed-loop on an inverted microscope, scan size 10 nm × 10 nm, height range 210 pm. Right: DNA origami (GATTA-AFM, Gattaquant, Germany) Tapping Mode topography image acquired at 400 lines/sec in TAE buffer, scan size 96 nm x 96 nm, height range 3.1 nm.
Operating Modes
Standard Operating Modes
- Now with PeakForce-QI including PeakForce Tapping, QI and PeakForce QNM
- Including fast PeakForce Tapping and QI with nested scanner technology
- Contact mode with lateral force microscopy (LFM)
- Tapping Mode™ with PhaseImaging™
- ExperimentPlanner for designing a specific measurement workflow
- Static and dynamic force spectroscopy
- Advanced Force Mapping
Optional Modes
- Advanced spectroscopy modes such as various force clamp modes or ramp designs
- Fast scanning option with line rates of up to 200 Hz
- QI Advanced mode for quantitative data, perfect for soft samples
- ScanAsyst automated gain and setpoint adjustment in PeakForce Tapping and PeakForce-QI
- Advanced AC modes such as FM and PM with Q-control & Active Gain Control
- Microrheology in CellMech Package
- Kelvin Probe Microscopy
- MFM and EFM
- Conductive AFM
- STM
- Electrical spectroscopy modes
- Piezoresponse Microscopy for high voltages
- Electrochemistry & Scanning Electrochemistry with temperature control and optical microscopy
- NanoLithography and NanoManipulation
- NanoIndentation
- Scanning Thermal AFM
- FluidFM® solution from Cytosurge
- ExperimentControl feature for remote experiment control
- DirectOverlay 2 for combined AFM and optical microscopy
- Additional XY or Z sample movement stages available with CellHesion®, TAO™ and HybridStage™ module
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