Dimension FastScan Bio
The Dimension FastScan Bio Atomic Force Microscope (AFM) enables high-resolution research of biological dynamics, with temporal resolution of up to 3 frames-per-second for live sample observations. What’s more, it does this while making the AFM easier to use than ever before. Built upon the world’s most advanced large-sample AFM platform, the FastScan Bio AFM adds specialized life science features to this platform for high-resolution, live-sample observation of interacting molecules, membrane proteins, DNA protein binding, inter-cellular signaling and many other dynamic biological studies.
High-Resolution Biological Dynamics
In-situ high-resolution dynamic studies with nanoscale resolution are a reality for a rapidly evolving branch of biological research. Dimension FastScan Bio breaks longstanding barriers to provide these capabilities for routine experimentation. These breakthroughs allow many more researchers to observe and study biomolecular structures and mechanisms. FastScan Bio’s high-resolution and high-speed scanning provide the best available bio tool for the observation of molecules, proteins, DNA, RNA, living cell membranes and tissues, and many other dynamics studies.
Time series of (1:1) DOPC/DPPC supported planar lipid bilayers. Consecutive images, recorded at 0.16 frames-per-second, demonstrate the stability of the taller DPPC gel phase domains and hence the highly sensitive force control of FastScan at high scan speeds. Imaging was conducted using TappingMode™ under aqueous conditions. Height images are shown. (Image size = 3μm; Z-scale = 3.2nm.)
Technology Designed for Live Samples
FastScan Bio’s innovative AFM technology enables high-speed scanning and a seamless user interface to render immediate panning, zooming and continuous tracking of samples in fluid. Bruker’s new innovative probe design with unique cantilever shape and coating enables an uprecedented combination of imaging speed and softness. The resulting system delivers the scanning speed required for high-resolution spatiotemporal studies with the greatest simplicity ever seen in a commercial AFM system.
- Simplified sample engaging and controls for immediate imaging
- Real-time panning, zooming and scanning
- Feature tracking and Movie creation tool
- Micro-volume fluid cell with controlled fluid exchange
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