NanoRacer High-Speed AFM
Highest imaging speed with up to 50 frames per second
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NanoRacer® High-Speed AFM
The NanoRacer® High-Speed AFM marks a quantum leap in quantitative imaging capabilities. The real-time visualization of dynamic biological processes with nanometer resolution has never been easier. The NanoRacer opens a world of new and exciting possibilities for Life Science applications, enabling researchers to gain an in-depth understanding of complex biological systems and molecular mechanisms, in a way not possible until now.
A new chapter in High-Speed AFM: Molecular dynamics in real-time at 50 frames and true 5000 lines per second
DNA origami nanostructures containing 5 biotin binding sites on mica, imaged in fluid with streptavidin presence in closed-loop at 50 frames and 5000 lines/sec. Click on the image to watch the video.
The NanoRacer opens a world of new and exciting possibilities for Life Science applications, enabling researchers to gain an in-depth understanding of complex biological systems and molecular mechanisms, in a way not possible until now:
- Single molecule binding behavior
- Dynamics in two-dimensional protein assemblies
- Enzyme activity monitoring
- Assembly and disassembly processes of protein structures
- DNA origami assembly
- Protein/protein interactions
- Motor protein and membrane trafficking dynamics
- Virus and bacteria morphology and dynamics
Outstanding resolution, renowned stability, remarkable accuracy
Atomic resolution of calcite crystal step edge, imaged in fluid, 3D topography 15 × 9 nm² [1], zoom 4 × 4 nm² [2]
Imaging atomic defects and sub-molecular resolution are now routine. The NanoRacer has the lowest noise levels of any commercial AFM system available, thanks to high precision electronics and enhanced accuracy positioning sensors in each axis.
The NanoRacer reflects the pioneering work of Bruker’s BioAFM team in combining technological advances with proven stability, sensitivity, and ease of use.
- Small cantilevers and lowest forces for minimum sample damage
- Infrared laser photothermal excitation option, for clean cantilever drive, easy setup and minimized perturbance of delicate samples
- Advanced algorithms for scanner control and feedback
- Minimized force drift for long-term experiments
- Highest bandwidth digital electronics, with lowest noise, for maximum performance
- Cutting-edge, high-speed power amplifier for perfect scanner drive
- Closed-loop scanning on all axes with minimal noise levels for highest accuracy
![Individual DNA molecules imaged in fluid on mica+PLO in closed loop. Sequences [4] + [5] are imaged at 50 frames/sec. Click on the image to watch the video.](https://www.bruker.com/en/products-and-solutions/microscopes/bioafm/jpk-nanoracer/_jcr_content/root/sections/features/sectionpar/twocolumns_179605772/contentpar-2/image.coreimg.82.860.jpeg/1673640113846/dna-50frames-per-second-500.jpeg)
Individual DNA molecules imaged in fluid on mica+PLO in closed loop. Sequences [4] + [5] are imaged at 50 frames/sec. Click on the image to watch the video.
Discover a new user experience – a complete system designed for convenience
- Easy sample and probe loading
- Transportable sample carrier for convenient sample preparation on the bench
- Probe exchange in a few minutes
- No calibration needed thanks to closed-loop scanner design
- Easy navigation with integrated camera for locating areas of interest on the sample
- Fluid exchange via direct injection
- Newly designed 3-port liquid cell for photothermal excitation
The NanoRacer marks a new chapter in high-speed AFM and relegates complicated, time-consuming procedures to the past. Developed with the user in mind, the resulting robust and reliable design, with a host of new features, make the NanoRacer easy to use, even for newcomers to AFM.
All components are designed for convenient handling, from sample preparation through to fully motorized and automatic optical alignment. The streamlined handling enables easy data collection and fast results. A short time-to-data is vital for achieving dynamic results on active single molecule samples.
- Automated cantilever alignment
- Optimized drift compensation
- Automated photothermal laser alignment option
- Internal camera with autofocus
- Automated calibration of cantilever spring constant
Seamless handling for preparation and imaging with the transportable sample scanner. Prepare the sample conveniently on the bench and load into the NanoRacer to image.
Operating Modes
Standard Operating Modes
Imaging modes
- Tapping Mode™ with PhaseImaging™
- Contact mode with lateral force microscopy (LFM)
Force measurements
- Static and dynamic spectroscopy
- Advanced force mapping
Optional Modes
- PeakForce™ Tapping for imaging
- Advanced AC modes such as FM and PM with Q-control & Active Gain Control
- Higher harmonics imaging
- NanoManipulation
- ExperimentPlanner™ for designing a specific measurement workflow
- RampDesigner™ for custom designed clamp and ramp experiments
- ExperimentControl™ feature for remote experiment control
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